The purpose of this study was to determine the pharmacokinetics of cannabidiol (CBD) in healthy dogs. Thirty, healthy research dogs were assigned to receive 1 of 3 formulations (oral microencapsulated oil beads, oral cannabidiol-infused oil, or cannabidiol-infused transdermal cream), at a dose of seventy-five milligrams or one hundred and fifty milligrams every twelve hours for six weeks.
Serial cannabidiol blood plasma concentrations were measured over the first twelve hours and repeated at two weeks, four weeks, and six weeks. Higher systemic exposures were observed with the oral cannabidiol-infused oil formulation and the half-life after a seventy-five milligram and one hundred and fifty milligram dose was approximately two hundred and one hundred and twenty-eight minutes, respectively.
Results from this study conclude that exposure is dose-proportional and that the oral cannabidiol-infused oil provides the most favorable pharmacokinetic profile.
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Effect of cannabidiol in healthy canines using 3 different methods